Thanks to its expertise, Prosol makes available the excellence of individual natural nucleotides under the trademark RIBOCARE

The brand RIBOCARE covers:
• 5′-AMP, Adenosine 5′-monophosphate free acid and Disodium salt;
• 5′-CMP, Cytidine 5′-monophosphate free acid and Disodium salt;
• 5′-UMP, Uridine 5′-monophosphate Disodium salt;
• 5′-GMP, Guanosine 5′-monophosphate Disodium salt;
• 5′-IMP, Inosine 5′-monophosphate Disodium salt.

Customized premix of individual Nucleotides for each specific application for infant milk or dietary supplements are manufactured in high care clean rooms, following the strictest procedures to guarantee the highest safety standards. Prosol guarantees the quality level and the accuracy of each individual Nucleotide profile in the recipe.

Nucleotides addition to infant milk is nowadays common for most of the market players and represents a common supplementation in nutrition of new born up to 6 months age and even further.

Why using Nucleotides

Nucleotides are really efficient for immune modulation and gut health

Since more than 20 years several demonstrated that feeding infants with Nucleotides is associated to a better anti-bodies response to vaccines. The data confirmed the positive effects of Nucleotides inclusion in milk without risk correlated.

In 2001, 2003, 2007 some studies collected and elaborated the results on different clinical experimentations conducted on several hospitalized subjects and feed with enteral foods. Many single studies and at least 5 meta-studies about the combination of different immune-modulating components, among which Nucleotides, gave positive homogeneous results. In particular a study conducted on 22 experimentations that involved approx 2000 patients, demonstrated a positive connection between enteral nutrition with integration of immune-modulating substances (nucleotides, arginine, omega-3, glutamine) and the decrease of complications due to infections.

Maternal Milk Substitutes

Maternal milk composition is one of the primary reference point for the formulation of infant foods. Data of the Nucleotides content in maternal milk are not always in accordance and they change on the basis of the method of analysis used, of the lactation phase and of the calculation or not of RNA and Nucleosid content. Anyway, maternal mature milk contains approx 10 mg/L Nucleotides.

Undoubtedly bovine milk contains less Nucleotides and in different proportion in comparison with human milk; besides, the heat treatment usually applied during productive phases, degrades the most of Nucleotides.

The main producers of infant formula established the Association of Infant Food Manufacturers (www.ifm.net). On the website of the Association there is a section titled “Nucleotides in Infant Formula” in which are resumed the features and functions of Nucleotides:

“Nucleotides (…) are not considered “essential” because can be synthesized by simple substances. Nevertheless in some moments, synthesis processes are not able to satisfy the demand; for example during the periods of rapid cells turnover, as during a normal growth process or in case of enteric disease. In those periods the body makes more use of dietary Nucleotides, therefore, especially in particular conditions, Nucleotides are considered “essential” when they have to be added to the diet.

Gastro-intestinal beneficial effects

Dietary Nucleotides act as “growth factors” on the gut cells, promoting their differentiation and maturation: a higher thickness of intestinal mucosa and of villis and an increased activity of the digestive enzymes are subsequent to the benefit on the intestinal cells. Beside higher villis surface and crypts depth increase upon inclusion of Nucleotides in the diet.

Besides, Nucleotides act improving intestinal immune defences and promoting bacteria growth, mostly Lactobacilli and Bifidobacteria to the detriment of the Gram negative bacteria, responsible of enteritis like Escherichia Coli.

Learning and memory improvement

The cerebral cells are not able to synthesize Nucleotides, therefore the dietary supply is focal for the central nervous system. Nucleotides stimulate the glial cells proliferation, promote the cerebral vascular circulation and improve the lipid metabolism of the cerebral cortex. Memory and learning improvements are naturally subsequent to the above, enhanced overall in elderly subjects.