Dietary Nucleotides act as “growth factors” on the gut cells, promoting their differentiation and maturation: a higher thickness of intestinal mucosa and of villi and an increased activity of the digestive enzymes are subsequent to the benefit on the intestinal cells. Beside higher villi surface and crypts depth increase upon inclusion of Nucleotides in the diet.
Different studies have shown a higher nutrients intestinal absorption, specifically Calcium, Phosphorous and carotenoids.
Besides, Nucleotides act improving intestinal immune defences and promoting bacteria growth, mostly Lactobacilli and Bifidobacteria to the detriment of the Gram-negative bacteria, responsible of enteritis like Escherichia Coli.
Immediate results are a higher disease and infections resistance, besides a more rapid recovery of enteritis and nutritional or protein privation.
Recent meta-studies on different clinical researches pointed out less diarrhoea events and an improvement of the composition of intestinal flora in comparison with subjects fed with milk not added with Nucleotides.
Various in vitro studies demonstrated the beneficial Nucleotides effect on Bifidobacteria. The reason of this effect could be due to the increase of ion Iron absorption, ion that promotes the development of Enterobacteria in the intestine and the fact that Nucleotides are a growth factor for Bifidobacteria, although overall, Nucleotides are absorbed as Nucleosides in the first gut tract. It seems that a percentage of approx. 10% of the dietary Nucleotides is present in the colon and there exercises its growing effect on Bifidobacteria.
A Nucleotides rich diet is very useful in the clinical and functional recovery of hepatic infections; actually, after hepatic intoxications, fibrosis and cirrhosis, the entity of
the damage is lower and the recovery is faster. The facts are that Nucleotides promote the hepatic activity, speeding up the protein synthesis, the glucose deposit, stopping cholesterol and other lipids storage.
The cerebral cells are not able to synthesize Nucleotides; therefore, the dietary supply is focal for the central nervous system. Nucleotides stimulate the glial cells proliferation, promote the cerebral vascular circulation and improve the lipid metabolism of the cerebral cortex. As consequence memory and learning improvements are naturally occurring, overall in elderly subjects.