Nucleotides in Infant Formula

Infants and newborns require very specific combinations of nutrients for their development and healthy growth.

The advantages of nucleotides in infant formula have been tested in clinical trials. The results of several studies suggest that nucleotides confer beneficial biological effects on the early stage of human life. For a baby, breast milk is the best, indeed maternal milk composition is one of the primary models for the formulation of infant foods. Mother’s milk contains nucleotides. That’s why some pharmaceutical companies in the baby formula market began to study the physiological importance of these molecules as well.


In vitro and in vivo studies showed that nucleotides affected the wellness of the intestinal barrier positively. They contribute to boost the immune response, especially lymphocytes maturation and antibodies expression (Ig) and, in newborn, foster bifidobacteria growth at intestinal level.

Nucleotides are usually used for infant formula in  pre-constitute mixes in order to make products more similar to mother’s milk. The main multinational companies worlwide have been including nucleotides for more than 30 years in number 1 and number 2 formulas.

Nucleotides have been commercially used in human infant formulas for many years, as a way of improving gastric development and early immune function.

(Helembai et al., 2006; Ruihua et al., 2006)

Prosol helps baby food manufacturers with high quality infant nutrition ingredients to support growth and immune system throughout the first years of life. Since 1999, Prosol is strategic supplier of nucleotides blends used for this market segment. The brand name for this product range is RIBOCARE®

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